Research

Transinsight collaborates closely with the bioinformatics group of TU Dresden.
The group has a comprehensive research programme funded with over 6.8 Million € dedicated to ontologies and textmining.
 

It covers the following topics:

  • design and evolution of bio-ontologies,
  • textmining to extract protein interactions and ontology terms in texts,
  • grid computing for bioinformatics,
  • analysis of high-throughput micro-array and RNAi data,
  • biomedical applications in particular cell-cycle and pancreas tumor, endocytosis and infectious diseases, osteoclast differentiation and bone diseases as well as membrane proteins. A list of all publications
  • life cell imaging and motion tracking (Kalaimoscope) in collaboration with the (MPI-CBG)
     
Cell 2010 Cover Nature 2010 Biophysical Journal 2009 Cover Nature 2008 Cover Cell 2008 Cover
Cell 10 Nature 10 Biophyical Journal 09 Molecular Systems Biology 08 Cell 08
A Minimal Midzone Protein Module Controls Formation and Length of Antiparallel Microtubule Overlaps Systems survey of endocytosis by multiparametric image analysis Obstacles on the Microtubule Reduce the Processivity of Kinesin-1 in a Minimal In Vitro System and in Cell Extract Membrane identity and GTPase cascades regulated by toggle and cut-out switches XMAP215 is a processive microtubule polymerase
Nature 2007 Cover Science 2007 Cover Nature 2006 Cover Cell 2005 Cover Nature 2003 Cover
Nature 07 Science 07 Nature 06 Cell 05 Nature 03
Reconstitution of a microtubule plus-end tracking system in vitro Kinetics of Morphogen Gradient Formation The depoly- merizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends Rab Conversion as a Mecha- nism of Progression from Early to Late Endo- somes RhoD regulates endosome dynamics through Diaphanous- related Formin and Src tyrosine kinase