Research

Transinsight collaborates closely with the bioinformatics group of TU Dresden.
The group has a comprehensive research programme funded with over 4.7 Million € dedicated to ontologies and textmining.

It covers the following topics:

• design and evolution of bio-ontologies,
• textmining to extract protein interactions and ontology terms in texts,
• grid computing for bioinformatics,
• analysis of high-throughput micro-array and RNAi data,
• biomedical applications in particular cell-cycle and pancreas tumor, endocytosis and infectious diseases, osteoclast differentiation and bone diseases as well as membrane proteins. A list of all publications
• life cell imaging and motion tracking (Kalaimoscope) in collaboration with the (MPI-CBG)

Nature 10	Biophyical Journal 09	Molecular Systems Biology 08	Cell 08	Nature 07
Systems survey of endocytosis by multiparametric image analysis	Obstacles on the Microtubule Reduce the Processivity of Kinesin-1 in a Minimal In Vitro System and in Cell Extract	Membrane identity and GTPase cascades regulated by toggle and cut-out switches	XMAP215 is a processive microtubule polymerase	Reconstitution of a microtubule plus-end tracking system in vitro
Science 07	Nature 06	Cell 05	Nature 03
Kinetics of Morphogen Gradient Formation	The depoly- merizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends	Rab Conversion as a Mecha- nism of Progression from Early to Late Endo- somes	RhoD regulates endosome dynamics through Diaphanous- related Formin and Src tyrosine kinase